Vertical wheel bioreactors
are single-use bioreactors produced by PBS Biotech. Central piece of these systems is a vertically integrated wheel in a U-shaped cultivation chamber, which is either driven magnetically or pneumatically (see pneumatically driven). The magnetically driven series was developed for applications with shear-sensitive cells and microcarriers (e.g. stem cells) in a working volume of between 20 mL and 15 L. The pneumatically-driven version is scalable between working volumes of 600 mL and 500 L and is recommended for animal cell cultures.