describes a selection process which serves the evaluation of high performance production cell lines, drug candidates, optimal bioprocess parameters or the optimal media composition. With the development of the single‑use technology, instrumented cultivation systems in the milliliter-scale were brought to the market with the idea of saving time. Beside automated microbioreactors, multiwell plates equipped with optical pH and oxygen sensors, shake flasks, T-flasks and TubeSpin bioreactors entered the market. The sensors (e.g. those produced by PreSens) are, in the latter case, spots glued to the inner surface of the transparent cultivation container and connected to a transmitter (which takes up the measuring signal and transfers it to the issuing point).