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Final filling

is the filling of a final formulation into primary drug containments such as flasks or syringes 23, 24. The final filling has specific requirements in order to guarantee sterility, integrity, the operational security and efficiency, as well as the correctness of the filling volumes 25.  The trend in final filling systems also moves towards single-use systems 25.

A single-use final filling system for medication usually consists of bags for storage and intermediate buffers, sterile filters with corresponding bags for the integrity testing, as well as a manifold system (see manifolds) with filling needles 26.