Single-Use-Technologie von A-Z

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  1. Eibl R, Eibl D. Single-Use Technology in Biopharmaceutical Manufacture. New Jersey: John Wiley & Sons; 2011.
  2. Hammond M, Nunn H, Rogers G, et al. Identification of a leachable compound detrimental to cell growth in single-use bioprocess containers. PDA J Pharm Sci Technol. 2013;67(2):123-34. Available at: Accessed November 13, 2014.
  3. Bestwick D, Colton R. Extractables and Leachables from Single-Use Disposables. Bioprocess Int Suppl. 2009;7(1):88-94.
  4. Eibl R, Eibl D, Pörtner R, Catapano G, Czermak P. Cell and Tissue Reaction Engineering. Heidelberg: Springer Verlag; 2009.
  5. Ducos JP, Terrier B, Courtois D. Disposable bioreactors for plant micropropagation and mass plant cell culture. Adv Biochem Eng Biotechnol. 2009;115:89-115.
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  7. Xcellerex. Eight Questions to Ask Before Planning Your Single-Use Biomanufacturing Facility.; 2009.
  8. Pietrzykowski M, Flanagan W, Pizzi V, et al. An environmental life cycle assessment comparing single-use and conventional process technology. Biopharm Int Suppl. 2011;24(11):30–38.
  9. Fenge C, Jurkiewicz E, Husemann U, et al. Consistently Superior Cell Growth. Bioprocess Int Suppl. 2014;12(8):2-5 (Reprint).
  10. Sartorius Stedim Biotech. BIOSTAT STR: True scaleability in single-use.; 2012;212: Broschüre.
  11. Furey J. Scale-up of a cell culture perfusion process - a low-shear filtration system that inhibits filter-membrane fouling. GEN. 2002;22:62.
  12. PreSens. Disposables with Integrated Sensors.; 2013. Available at: Accessed May 18, 2015.
  13. Jenke D, Odufu A, Poss M. The effect of solvent polarity on the accumulation of leachables from pharmaceutical product containers. Eur J Pharm Sci. 2006;27(2-3):133-42. Available at: Accessed November 13, 2014.
  14. Lehmann N, Rischer H, Eibl D, Eibl R. Wave-Mixed and Orbitally Shaken Single-Use Photobioreactors for Diatom Algae Propagation. Chemie Ing Tech. 2013;85(1-2):197-201. doi:10.1002/cite.201200137.
  15. Lehmann N, Dittler I, Lämsä M, et al. Disposable bioreactors for the cultivation of plant cell cultures. In: Dee-Yoeup, P; Hosakatte Nirjanjana MJ-JZ, ed. Production of Biomass and Bioactive Compounds using Bioreactor Technology. Dordrecht: Springer Netherlands; 2014:17-46.
  16. Szczypka M, Splan D, Wools H, et al. Single-Use Bioreactors and Microcarriers Scalable Technology for Cell-Based Therapies. Bioprocess Int. 2014;12(3):56-64.
  17. Eibl R, Steiger N, Fritz C, et al. Standardized cell culture test for the early identification of critical films for cho cell lines in chemically defined culture media. Frankfurt am Main: DECHEMA; 2014. ISBN: 978-3-89746-149-9.
  18. Eibl D, Eibl R, Köhler P, et al. Single-Use Techologie in der biopharmazeutischen Produktion; DECHEMA; 2012. Available at: Accessed May 18, 2015.
  19. Kraume M. Transportvorgänge in der Verfahrenstechnik: Grundlagen und apparative Umsetzungen. Berlin: Springer Verlag; 2012.
  20. Kaiser SC, Kraume M, Eibl D, Eibl R. Single-use bioreactors for animal and human cells. In: Al-Rubeai M, ed. Animal Cell Culture. Springer International Publishing Switzerland; 2015:445-499.
  21. Singh SK, Kohle P, Wang W, et al. Large-scale freezing of biologics: a practioner`s review. Part one: fundamental aspects. Bioprocess Int. 2009;(7):32-44.
  22. Bögli N, Ries C, Adams T, Greller G, Eibl R, Eibl D. Large-scale, insect-cell-based vaccine development. BioProcess Int Suppl. 2012;10:40-49.
  23. Rathore N, Rajan RS. Current perspectives on stability of protein drug products during formulation, fill and finish operations. Biotechnol Prog. 2008;24(3):504-14. Available at: Acessed May 18, 2015.
  24. Rios M. A decade of fill-finish and packaging solution. Bioprocess Int. 2012;10(6):54-56.
  25. Jenness E, Gupta V. Implementing a Single-Use Solution for Fill-Finish Manufacturing Operations. Bioprocess Int Suppl. 2011;9(2):22-26.
  26. Sartorius Stedim Biotech. FlexAct Multi Fill.; 2013. Available at: Accessed May 18, 2015.
  27. Kadarusman J, Bhatia R, McLaughlin J, Lin W. Growing cholesterol-dependent NSO myeloma cell line in the wave bioreactor system: overcoming cholesterol-polymer interaction by using pretreated polymer or inert fluorinated ethylene propylene. Biotechnol Prog. 2005;21:1341-6.
  28. Pörtner R, Schawbe J, Frahm B. Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line. Biotechnol Appl Biochem. 2004;40:47-55.
  29. Merck Millipore AG. The Mobius FlexReady Solution for TFF; 2015. Available at:,MM_NF-C100747: Accessed May 18, 2015.
  30. Blaschczok K, Steiger N, Jurkiewicz E, et al. Evaluation of a new film type for single-use bags. GEN 2015; in press.
  31. Jurkiewicz E, Husemann U, Greller G, Barbaroux M, Fenge C. Verification of a new biocompatible single-use film formulation with optimized additive content for multiple bioprocess applications. Biotechnol Prog. 2014;30(5):1171-6. Available at: Accessed January 9, 2015.
  32. Nutek. E beam vs. Gamma sterilization. 2008. Available at: Acessed May 18, 2015.
  33. Vanhamel S, Masy C. Production of Disposable Bags: A Manufacturer’s Report. In: Eibl R, Eibl D, eds. Single-use technology in biopharmaceutical manifacture. Hoboken, New Jersey: John Wiley & Sons; 2011:114-133.
  34. Wright B, Bruninghaus M, Vrabel M, et al. A Novel Seed-Train Process: Using High-Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies. Bioprocess Int Suppl. 2015 ; 3(1) . Available at: Accessed March 24, 2015.
  35. Yang WC, Lu J, Kwiatkowski C, et al. Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality. Biotechnol Prog. 2014;30:616-625.
  36. Eibl R, Löffelholz C, Eibl D. Single-Use Bioreactors - An Overview. In: Eibl R, Eibl, eds. Single-use Technol. Biopharm. Manuf. Hoboken, New Jersey; 2011:34-47.
  37. Eibl R, Steiger N, Wellnitz S, et al. Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study. Adv Biochem Eng Biotechnol. 2014;138:99-1215.
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  39. Hernández Rodríguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. BMC Proc Suppl. 2013;7(6):P9: Available at Accessed December 10, 2014.
  40. Glindkamp A, Riechers D, Rehbok C, Hitzmann B, Scheper T, Reardon K. Sensors in Disposable Bioreactors Status and Trends. In: Eibl R, Eibl D, eds. Disposable Bioreactors. Heidelberg: Springer Verlag; 2010:145-169.
  41. Lindner P, Endres C, Bluma A, et al. Disposable Sensor Systems. In: Eibl R, Eibl D, eds. Single-use technology in biopharmaceutical manufacture. Hoboken, New Jersey: John Wiley & Sons; 2011:68-77.
  42. Czermak P, Pörtner R, Brix A. Special Engineering Aspects. In: Eibl R, Eibl D, Pörtner R, Catapano G, Czermak P, eds. Cell and Tissue Reaction Engineering. Heidelberg: Springer Verlag; 2009:83-172.
  43. Langer E. Perfusion bioreactors are making a comeback but industry misperceptions persist. Bioprocess Int. 2011;9(2):49-52.
  44. Tappe A, Gottschalk U. Single-Use Downstream Equipment. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf. Hoboken, New Jersey: John Wiley & Sons; 2011:92-102.
  45. Eibl D, Kaiser SC. Single-Use-Pumpen in der Bioprozesstechnologie. Chemie Extra. 2013;10:30-31.
  46. Riesen N, Eibl R. Single-Use Bag Systems for Storage, Transportation, Freezing and Thawing. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf. Hoboken, New Jersey: John Wiley & Sons; 2011:14-20.
  47. Fuller BJ. Cryoprotectants: the essential antifreezes to protect life in the frozen state. Cryo Letters. 2004;25(6):375-88.
  48. Murhammer D. Baculovirus and Insect Cell Expression Protocols. Second. Totowa: Humana Press Inc; 2007.
  49. Goldstein A. Freeze Bulk Bags: A Case Study in Disposables Implementation. Biopharm Int. 2009;22(11):4-14.
  50. McDonald GR, Hudson AL, Dunn SMJ, et al. Bioactive contaminants leach from disposable laboratory plasticware. Science 2008;322(5903):917.
  51. Hammond M, Marghitoiu L, Lee H, et al. A cytotoxic leachable compound from single-use bioprocess equipment that causes poor cell growth performance. Biotechnol Prog. 2014;30(2):332-337.
  52. Steiger N, Eibl R. Interlaboratory Test for Detection of Cytotoxic Leachables arising from Single-Use Bags. Chemie Ing Tech. 2012;85(1-2):26-28.
  53. PALL. Micro-24 MicroREactor System; 2015. Available at: Accessed May 18, 2015.
  54. Hemmerich J, Kensy F. Automation of Microbioreactors: Operating 48 Parallel Fed-Batch Fermentations of Microscale. Bioprocess Int. 2013;11(8):68-76.
  55. Eibl R, Brändli J, Eibl D Plant cell bioreactors, in biotechnology. Encyclopedia of life support systems (EOLSS), Developed under the auspices of the UNESCO, Eolss Publishers, Oxford, UK; 2012. Available at: Accessed March 03, 2014.
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  57. Baier U. Generation and Treatment of waste from single-use systems. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf. Hoboken, New Jersey: John Wiley & Sons; 2011:174-181.
  58. Sinclair BA, Leveeen L, Monge M, et al. The Environmental Impact of Disposable Technologies. Biopharm Int. 2008;21(11):1-9. Available at: Accessed May 18, 2015.
  59. Droror E. LEVITRONIX Bearingless Pump Technology Technical backgrounds and their meaning for pharmaceutical- and biopharmaceutical production.; 2011. Available at: Acessed May 18, 2015.
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  61. Kim J, Seong J, Lee B, Hashimura Y, Groux D, Oh D. Evaluation of a novel pneumatic bioreactor system for culture of recombinant Chinese hamster ovary cells. Biotechnol Process Eng. 2013;18:801-807.
  62. Lee B, Langer E, Zheng R. Next-generation single-use bioreactor technology and the future of biomanufacturing: A summary from the manufacturer’s and user' perspective. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf. Wiley Verlag; 2011:183-195.
  63. Barbaroux M, Gerighausen S, Hackel H. An approach to quality and security of supply for single-use bioreactors. Adv Biochem Eng. 2014;138:239-272.
  64. Sartorius Stedim Biotech. GammaTag-Integrated Lifecycle Management; 2015. Available at: Accessed May 18, 2015.
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  66. Qualitz J. Using fluorescence-based sensing to accelerate process development. Biopharm Int. 2009;22(6):50
  67. Rothe S, Eibl D. Systems for Coupling and Sampling. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf. Hoboken, New Jersey: John Wiley & Sons; 2011:54-64.
  68. Bernard F, Chevalier E, Cappia JM, et al. Disposable pH sensors. Bioprocess Int Suppl. 2009;7(1):32-36.
  69. ISPE. Glossary of Pharmaceutical and Biotechnology Terminology; 2015. Available at : Accessed May 18, 2015.
  70. Sherman HA, Upton T. Disposable Spinner Flasks for Scale Up or Production of Proteins ; 2015. Available at : Accessed May 18, 2015.
  71. Shaw R. Stem-cell-based therapies: What`s in development, implications for bioprocessing. BioProcess Int Suppl. 2011;9(1):20-25.
  72. Pörtner R. Characteristics of Mammalian Cells and Requirements for Cultivation. In: Eibl R, Eibl D, Pörtner R, Catapano G, Czermak P, eds. Cell and Tissue Reation Engineering. Heidelberg; 2009:13-53.
  73. Rodrigues ME, Costa AR, Henriques M, et al. Advances and drawbacks of the adaptation to serum-free culture of CHO-K1 cells for monoclonal antibody production. Appl Biochem Biotechnol. 2013;196(4):1279–91.
  74. PALL. Nucleo Single-Use Bioreactor ; 2015. Available at: Accessed May 18, 2015.
  75. Pastor A, Barbe S. Disposable Chromatography for Large-Scale Biomanufacturing. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf.2. Hoboken, New Jersey: John Wiley & Sons; 2011:302-308.
  76. Suma R, Dolan S. Single-Use Virus Clearance Technology in Biopharmaceutical Manifacturing: Case Studies. In: Eibl R, Eibl D, eds. Single-use Technol. Biopharm. Manuf. Hoboken, New Jersey: Wiley Verlag; 2011:312-321.
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  78. Diel B, Manzke C, Peuker T. Flexible Biomanufacturing Processes that Address the Needs of the Future. Adv Biochem Eng Biotechnol. 2014;138:207-237.
  79. Eibl R, Kaiser S, Lombriser R, et al. Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology. Appl Microbiol Biotechnol. 2010;86(1):41-49.
  80. Catapano G, Czermak P, Eibl R, Eibl D, Pörtner R. Bioreactor Design and Scale-Up. In: Eibl R, Eibl D, Catapano G, Czermak P, Pörtner R, eds. Cell and Tissue Reation Engineering. Heidelberg: Springer Verlag; 2009:173-262.
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